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See Latest ArticlesSTK15 F31I polymorphism is associated with breast cancer risk: a meta-analysis involving 25,014 subjects
Breast Cancer Research and Treatment, 10/26/09
Qiu LX et al. – This meta-analysis suggests that the STK15 31II allele is a low-penetrant risk factor for developing breast cancer.
Methods- Meta-analysis was performed. Medline, PubMed, Embase, Web of Science, and Chinese Biomedicine Database were searched
- Crude ORs with 95% CIs used to assess strength of association between the STK15 F31I polymorphism and breast cancer risk
- Pooled ORs performed for codominant model , dominant model , and recessive model , respectively
- Total of 10 studies including 10,537 cases and 14,477 controls involved in meta-analysis
- Overall, significantly elevated breast cancer risk associated with II variant genotype in homozygote comparison and recessive genetic model when all studies were pooled into the meta-analysis
- In subgroup analysis by ethnicity, significantly increased risks were found for II allele carriers among Caucasians ; for recessive model: OR = 1.21, 95% CI = 1.00–1.45); significantly increased risks were also found among Asians for II versus FF
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