Oncology Medical News about Lactate dehydrogenase

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Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
Modern Pathology, 10/23/09

Zhuang L et al. – The low Bcl–2 expression in melanomas with high LDH–5 expression provides an explanation for the poor response of patients with high serum LDH levels to treatment with the Bcl–2 antisense drug 'Genasense'. The strong correlation of LDH–5 expression with Mcl–1 expression suggests that treatment strategies inhibiting the activity of Mcl–1 in melanoma patients should be investigated.

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