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Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency
Genes, Chromosomes and Cancer, 10/22/09
Rennstam K et al. – The results imply that genomic instability instigated by BRCA1 haploinsufficiency may be required for breast cancer initiation in BRCA1 mutation carriers. Finding molecular markers of tumor initiation and progression, for the potential use in early disease detection, may be of great clinical importance for the improved management of at–risk women.
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Today in Basic Science/Genetics...keeping you current
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Today in Breast...keeping you current
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Association between global DNA hypomethylation in leukocytes and risk of breast cancer
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