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Partial T cell-depleted allogeneic SCT following reduced intensity conditioning creates a platform for immunotherapy with donor lymphocyte infusion and recipient dendritic cell vaccination in multiple myeloma
Biology of Blood and Marrow Transplantation, 10/22/09
Levenga H et al. – DC–vaccination was associated with limited toxicity and none of these patients developed GVHD. Importantly, overall treatment–related mortality at one year was low (10%). Moreover, the overall survival is 85% with median follow–up of 27 months, and none of the patients died from progressive disease. These findings illustrate that this novel approach is associated with limited GVHD and mortality, thus creating an ideal platform for adjuvant immunotherapy.
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Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
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