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Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma
Cancer Epidemiology, 10/22/09
Gold LS et al. – CYP1B1 activates chemicals such as polycyclic aromatic hydrocarbons and dioxins to create oxidized, reactive intermediates, and higher gene activity has been shown for the G allele. The authors conducted the largest analysis to date on MM and these genetic variants and our results provide preliminary evidence that variation in CYP1B1 may influence susceptibility to MM.
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