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Obesity is associated with atypia in breast ductal lavage of women with proliferative breast disease
Cancer Epidemiology, 10/19/09

Djuric Z et al. –Although the clinical significance of atypia in breast ductal lavage is uncertain, these results support further work on prevention of obesity as a strategy for reducing breast cancer risk.

• Pilot study of women with past diagnosis of proliferative breast disease with goal to determine if characteristics of cells obtained by breast ductal lavage were related to nutritional factors

• 57 women enrolled
• Total of 39 women yielded nipple aspirate fluid (NAF) samples and 36 underwent breast ductal lavage
• 5 of lavage samples acellular and 28 had at least 200 cells. Surprisingly
• Atypia present in 11 women
• Presence of atypia associated with slight changes in morphometric features of epithelial cells such as measures of circularity as obtained by image analysis, but only variable significantly different in women with atypia (versus no atypia) was higher mean BMI
• BMI also significantly correlated with CRP levels in nipple aspirate fluid, indicating that obesity might have pro-inflammatory effect on breast that can contribute to increased rates of atypia

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