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Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
Annals of Oncology, 10/16/09

Mar Fan HG et al. – Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.

Methods

41 women who had undergone menopause as result of chemotherapy and 57 healthy women who had undergone recent natural menopause evaluated on 2 occasions 1 year apart
Primary end point was summed score of self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale
Quality of life evaluated by FACT-G questionnaire and fatigue by FACT-F subscale

Results

Strong trend for patients to report worse FACT-ES scores than controls at first and second time points
More patients had moderate/severe hot flashes than controls undergoing natural menopause (51% versus 19%)
Patients reported worse fatigue than controls at first assessment , with no difference at the second
Menopausal symptoms associated with fatigue for both groups
No difference between patients and controls in quality-of-life scale

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