Oncology Medical News about acute promyelocytic leukemia

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Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia - triggering the differentiation syndrome
Blood, 11/02/09

Luesink M et al. – Differentiation therapy may induce chemokine production in the lung and in APL cells, which both trigger migration of leukemic cells. Since dexamethasone does not efficiently reduce leukemic chemokine production, pulmonary infiltration of leukemic cells may induce an uncontrollable hyper–inflammatory reaction in the lung.

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Identification of a myeloid committed progenitor as the cancer initiating cell in acute promyelocytic leukemia
Blood, 10/09/09 Relevance Score: 81%

Additional chromosome abnormalities in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy
Haematologica, 11/16/09 Relevance Score: 80%

Secondary clonal cytogenetic abnormalities following successful treatment of acute promyelocytic leukemia
American Journal of Hematology, 10/13/09 Relevance Score: 80%

Therapy-induced PML/RARA Proteolysis and Acute Promyelocytic Leukemia Cure
Clinical Cancer Research, 10/12/09 Relevance Score: 80%

New advances in the treatment of acute promyelocytic leukemia
International Journal of Hematology, 10/07/09 Relevance Score: 80%