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Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma
Blood, 11/02/09
Li B et al. – The triple mutant, which was demonstrated to efficiently initiate both caspase–dependent and –independent apoptosis, exhibited potent in vivo therapeutic efficacy, even in the rituximab–resistant lymphoma model, suggesting that it might be a promising therapeutic agent for B–cell lymphomas.
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