Oncology

Your Article Summary

See Latest Articles

Local excision alone without irradiation for ductal carcinoma in situ of the breast: A trial of the Eastern Cooperative Oncology Group
Journal of Clinical Oncology, 10/19/09

Hughes LL et al. – Rigorously evaluated and selected patients with low- to intermediate-grade DCIS with margins 3 mm or wider had an acceptably low rate of ipsilateral breast events at 5 years after excision without irradiation. Patients with high-grade lesions had a much higher rate, suggesting that excision alone is inadequate treatment.

• Patients with either low- or intermediate-grade DCIS
• Measuring 2.5 cm or smaller, or high-grade DCIS measuring 1 cm or smaller with microscopic margin widths of 3 mm or wider
• No residual calcifications on postoperative mammograms eligible for prospective trial conducted from 1997 to 2002 by Eastern Cooperative Oncology Group and North Central Cancer Treatment Group
• Patients entered in 2000 and later could take tamoxifen if desired
• Median age at last surgery for entire population was 60 years (range, 28 to 88 years), and median tumor sizes in 2 strata were 6 mm and 5 mm, respectively

• With median follow-up of 6.2 years, 5-year rate of ipsilateral breast events in 565 eligible patients in low/intermediate grade stratum was 6.1%
• With median follow-up of 6.7 years, this incidence for 105 eligible patients in high-grade stratum was 15.3%

Today in Breast...keeping you current

Receive free subspecialty "5-minute updates" via email

Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis
Cancer Letters, 11/20/09

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors
Molecular Cancer, 11/20/09

Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration
World Journal of Surgical Oncology, 11/20/09

 See all of Breast