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See Latest ArticlesMethotrexate-induced myelopathy responsive to substitution of multiple folate metabolites
Journal of Neuro-Oncology, 10/30/09
Ackermann R et al. – Methotrexate (MTX)–associated myelopathy is a rare but serious subacute complication of MTX–based chemotherapy. The authors report the case of a woman with breast cancer and meningeal carcinomatosis who developed severe progressive myelopathy after four cycles of intrathecal MTX administration. Substitution with multiple folate metabolites may be a promising strategy for the treatment of MTX–induced neurotoxicity.
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