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Prolonged facial edema is an indicator of poor prognosis in patients with head and neck squamous cell carcinoma
Supportive Care in Cancer, 10/16/09

Chen MH et al. – The purpose of this study was to identify the causes of prolonged facial edema and its associations with other clinical factors. Prolonged facial edema may reflect the underlying disease status, and it can be applied as a prognostic marker in patients with HNSCC.

• Medical records from 264 patients with HNSCC reviewed
• Prolonged facial edema defined as persistence of edematous status (largest thickness >5 mm by CT scan) for > 100 days
• Clinical data including age, gender, tumor stage, and tumor primary sites recorded
• Statistical analyses performed to determine prognostic effect of prolonged facial edema, as well as relationship to other clinical variables
• Etiology of prolonged facial edema also analyzed

• Prolonged facial edema occurred in 32 (12.1%) patients
• Etiologies included internal jugular vein thrombosis, local infection, neck lymph nodes dissection, flap reconstruction, and direct vessel compression by tumors or metastatic lymph nodes
• No significant difference in incidence of prolonged facial edema in patients receiving different treatment modalities
• Patients receiving neck dissection correlated with occurrence of late-onset facial edema

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