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See Latest ArticlesRole of efflux pump activity in lapatinib/caelyx combination in breast cancer cell lines
Anti-Cancer Drugs, 10/19/09
Vannini I et al. – The data indicate that lapatinib used in combination with caelyx is active in HER2–expressing cells, probably because of lapatinib–induced dephosphorylation of the HER2–EGFR pathway, and also in non–HER2–expressing cells, possibly because lapatinib blocks efflux pump activity, increasing the length of time of intracellular exposure to caelyx and thereby increasing its cytotoxic effect.
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Today in Basic Science/Genetics...keeping you current
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The Role of Platelet and Fibrin Ultrastructure in Identifying Disease Patterns
Pathophysiology of Haemostasis and Thrombosis, 12/14/09
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Today in Breast...keeping you current
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Brain metastases in HER2-positive breast cancer: The evolving role of lapatinib
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Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: A retrospective analysis of a randomised trial
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Increased H2O2 level in exhaled breath condensate in primary breast cancer patients
Journal of Cancer Research & Clinical Oncology, 12/14/09
Today in Pharmacology/Therapy...keeping you current
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Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol
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The combination of thalidomide, cyclophosphamide and dexamethasone is potentially useful in highly resistant Hodgkins lymphoma
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