Oncology Medical News about cord blood transplantation

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Single unit dominance following double unit umbilical cord blood transplantation coincides with a specific CD8+ T cell response against the non-engrafted unit
Blood, 11/02/09

Gutman JA et al. – The data provide the first direct evidence in human double unit CBT recipients that immune rejection mediated by effector CD8+ T cells developing after CBT from naive precursors is responsible for the failure of one unit to engraft. Future investigations based on these findings may result in strategies to predict a dominant unit and enhance graft–versus–leukemia (GVL) effect.

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History of cord blood transplantation
Bone Marrow Transplantation, 10/07/09 Relevance Score: 84%

Single versus double unrelated umbilical cord blood units for allogeneic transplantation in adults with advanced haematological malignancies: a retrospective comparison of outcomes
Internal Medicine Journal, 11/11/09 Relevance Score: 82%

U of M researchers find 2 units of umbilical cord blood reduce risk of leukemia recurrence
EurekAlert, 11/16/09 Relevance Score: 80%

Cord blood transplantation in adults
Bone Marrow Transplantation, 10/07/09 Relevance Score: 80%

Umbilical cord blood transplantation for non-malignant diseases
Bone Marrow Transplantation, 10/07/09 Relevance Score: 80%