Oncology Medical News about acute lymphoblastic leukemia

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The impact of prophylactic fresh frozen plasma and cryoprecipitate on the incidence of CNS thrombosis and hemorrhage in children with acute lymphoblastic leukemia receiving asparaginase
Blood, 11/02/09

Abbott LS et al. – Asparaginase (ASP) therapy is associated with depletion of antithrombin (AT) and fibrinogen (FG). Potential toxicities include CNS thrombosis (CNST) and hemorrhage. Neither FFP nor CRY protected against CNST, suggesting prophylaxis is unwarranted for unselected ALL patients. However, prophylactic replacement for HR patients in induction may be appropriate and cost–effective.

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Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia
Blood, 11/13/09 Relevance Score: 81%

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics and outcome from the large randomised prospective trial (UKALL XII/ECOG 2993)
Blood, 11/02/09 Relevance Score: 81%

Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia
International Journal of Hematology, 10/13/09 Relevance Score: 81%

Outcome of childhood acute lymphoblastic leukemia with induction failure treated by the Japan Association of Childhood Leukemia Study (JACLS) ALL F-protocol
Pediatric Blood & Cancer, 10/09/09 Relevance Score: 81%

Concurrent intensive chemotherapy and imatinib before and after stem cell transplantation in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Final results of the CSTIBES02 trial
Haematologica, 10/07/09 Relevance Score: 80%