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Interaction between organochlorines and the AHR gene, and risk of non-Hodgkin lymphoma
Cancer Causes and Control, 10/14/09

Ng CH et al. – Plasma organochlorines have been implicated to increase the risk of non-Hodgkin lymphoma (NHL), and interaction with the aryl hydrocarbon receptor gene (AHR) may modify this risk.These results suggest that the AHR gene may play a role in determining the risk of NHL with exposure to organochlorines, and highlight the importance of understanding gene-environment interactions.

Methods

Case–control study
5 single nucleotide polymorphisms (SNPs) of AHR genotyped in 422 NHL cases and 459 controls to measure association between individual SNPs, haplotypes, and risk of NHL
Pre-chemotherapy organochlorine levels measured and gene–environment interaction analysis performed

Results

IVS1 + 4640G/A SNP was significantly associated with NHL risk, with odds ratio of 1.32 (95% CI = 1.05–1.65) for G/A or A/A genotypes compared to G/G genotype
Interactions observed with PCB 118, a known inducer of AHR, and chlordane-related analytes oxychlordane and trans-nonachlor, although no interactions statistically significant after controlling for multiple comparisons
Observed interactions consistent across NHL subtypes

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