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Severe sickle cell disease – pathophysiology and therapy
Biology of Blood and Marrow Transplantation, 10/15/09

Buchanan G et al. – Over 70,000 people live with sickle cell disease in the United States and multitudes world wide. About 2,000 afflicted babies are born in this country each year. There is growing understanding of the pathophysiology of the disease, and this, coupled with advances in transplantation and new approaches to therapy continue to improve care of patients with sickle cell disease both in children and during adulthood. Continuing investigation seeks to predict the course of the disease and to determine timing and modality of therapy in order to optimize outcomes.

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