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See Latest ArticlesMatrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage
Oncogene, 10/16/09
Provenzano PP et al. – The current data provide compelling evidence for the importance of the mechanical features of the microenvironment, and suggest that mechanotransduction in these cells occurs through a FAK–Rho–ERK signaling network with extracellular signal–regulated kinase (ERK) as a bottleneck through which much of the response to mechanical stimuli is regulated. Increased matrix stiffness explains part of the mechanism behind increased epithelial proliferation and cancer risk in human patients with high breast tissue density.
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Today in Basic Science/Genetics...keeping you current
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Gene-expression-based analysis of local and metastatic neuroblastoma variants reveals a set of genes associated with tumor progression in neuroblastoma patients
International Journal of Cancer, 12/15/09
BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer
International Journal of Cancer, 12/15/09
Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells
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Today in Breast...keeping you current
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BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer
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Systematic Review: Comparative Effectiveness of Core-Needle and Open Surgical Biopsy to Diagnose Breast Lesions
Annals of Internal Medicine, 12/15/09
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