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CyclinD1 and interleukin-1 receptor antagonist polymorphisms are associated with prognosis in neoadjuvant-treated gastric carcinoma
European Journal of Cancer, 10/27/09

Stocker G et al. – The cyclinD1 and IL-1RN polymorphisms were associated with survival. The combination of specific cyclinD1 and IL-1RN genotypes showed a particular prognostic relevance and should be considered an independent prognostic marker for neoadjuvant-treated gastric cancer patients.

Methods

178 patients who received platinum/5FU-based chemotherapy were genotyped for 10 polymorphisms in nine genes
Genotypes correlated with histopathological and clinical response and overall (OS) and progression-free survival (PFS)

Results

Only the cyclinD1 genotypes associated with clinical response
Significantly worse survival rates noted in patients homozygous for the G-allele as compared to patients with the AG or AA genotypes of the cyclinD1 polymorphism (OS: Plog-rank=0.024; PFS: Plog-rank=0.007) and in patients homozygous for the short allele compared to all other genotypes at the IL-1RN polymorphic locus (OS: Plog-rank=0.026; PFS: Plog-rank=0.013)
Combination of both unfavourable genotypes demonstrated strong prognostic relevance
Multivariate analysis for OS in group of completely resected patients (n=139) revealed statistical significance for ypM , histopathological response and the combined cyclinD1/IL-1RN genotypes

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