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Stage I breast cancer in a regional oncology practice in Israel 2002-2006: Clinicopathologic features, risk estimation and planned therapy of 328 consecutive patients
The Breast, 10/15/09

Geffen DB et al. – Individualized risk estimation by genetic analysis may further decrease the use of chemotherapy in stage I patients. Breast cancer screening may provide an opportunity to identify cancer prone families.

• Predicted 10-year mortality risk was calculated using the Adjuvant! Online website
• Present the clinicopathologic features and treatment plans of 328 consecutive stage I (T1N0M0) breast cancer patients seen at regional medical center
• 21-gene recurrence score (RS) (OncotypeDx™) obtained on minority of patients.

• 89 per cent of patients had estrogen receptor (ER) and/or progesterone receptor (PgR) positive tumors
• In 43.3% of patients history of invasive malignancy reported in first degree relative and in 15.5% specifically breast and/or ovarian cancer was reported
• Chemotherapy added to endocrine therapy in 59 ER/PgR positive patients, decreasing predicted 10-year mortality risk by median of 1.8%

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