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In Lynch syndrome adenomas, loss of mismatch repair proteins is related to an enhanced lymphocytic response
Histopathology, 10/15/09

Meijer TWH et al. – Lynch syndrome–associated tumours are characterized by the presence of an increased number of tumour–infiltrating lymphocytes. This enhanced lymphocytic response may be elicited by genetically altered proteins that may arise as a result of a defective DNA mismatch repair system. There is a correlation between the loss of mismatch repair proteins and the infiltration of lymphocytes in Lynch syndrome–associated adenomas.

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