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See Latest ArticlesSequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia
British Journal of Haematology, 10/16/09
Chauncey TR et al. – Patients with phenotypic or functional P–glycoprotein had somewhat higher CR rates with ADC than AD, although confidence intervals overlapped. In these sequential trials, continuous infusion AD produced CR rates comparable to those with bolus daunorubicin. The addition of ciclosporin did not cause undue toxicities, produced a similar CR rate, and possibly improved relapse–free survival. Further correlate analyses did not identify a subpopulation specifically benefitting from the addition of ciclosporin.
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