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See Latest ArticlesSelecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers
BMC Cancer, 10/14/09
Miolo GM et al. – These findings suggest that the IHC analysis by Allred's method improves our ability to select patients for BRCA1 testing.
Methods- Primary breast tumours from 93 FBC patients defined by specific eligibility criteria, based on personal and familial tumour history, evaluated by Allred's method
- BRCA1 molecular analysis, including Multiplex Ligation-dependent Probe Amplification (MLPA), considered as gold standard assay
- Total of 10 BRCA1 pathogenetic mutations found
- With exclusion of tumours characterized by double positive receptorial status and/or strong HER2 positivity (3+)
- Identified 22 patients, 10 of whom resulted as BRCA1 mutation carriers
- Sensitivity, specificity, positive and negative predictive values 100%, 83.3%, 45.4% and 100% respectively
Today in Basic Science/Genetics...keeping you current
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Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer
Cancer Treatment Reviews, 12/04/09
Dysregulation of Platelet-Derived Growth Factor beta-Receptor Expression by deltaNp73 in Neuroblastoma
Molecular Cancer Research, 12/04/09
Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression
Virchows Archiv, 12/04/09
Today in Breast...keeping you current
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Bevacizumab and breast cancer: current therapeutic progress and future perspectives
Expert Review of Anticancer Therapy, 12/04/09
Overall survival benefit for weekly vs. three-weekly taxanes regimens in advanced breast cancer: A meta-analysis
Cancer Treatment Reviews, 12/04/09
Switching from tamoxifen to aromatase inhibitors for adjuvant endocrine therapy in postmenopausal patients with early breast cancer
Cancer Treatment Reviews, 12/04/09
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