Oncology Medical News about thymidylate synthase

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Significance of thymidylate synthase for resistance to pemetrexed in lung cancer
Cancer Science, 10/23/09

Ozasa H et al. – The alteration of molecular pharmacological factors in relation with pemetrexed resistance is dose–dependent, and that up–regulation of the expression of the TS gene may have an important role in the acquired resistance to pemetrexed. In addition, TS may be a predictive marker for pemetrexed sensitivity in lung cancer.

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Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: The FOCUS Trial
Journal of Clinical Oncology, 10/30/09 Relevance Score: 64%

Relationship of polymorphism of the tandem repeat sequence in the thymidylate synthase gene and the survival of stage III colorectal cancer patients receiving adjuvant 5-flurouracil-based chemotherapy
Journal of Surgical Oncology, 10/05/09 Relevance Score: 64%

Inducible and endothelial nitric oxide synthase expression in human atherogenesis: an immunohistochemical and ultrastructural study
Cardiovascular Pathology, 11/06/09 Relevance Score: 42%

Effect of Genetic Variation in the Human Fatty Acid Synthase Gene (FASN) on Obesity and Fat Depot-Specific mRNA Expression
Obesity, 11/10/09 Relevance Score: 41%

Dysregulation of Glycogen Synthase COOH- and NH2-Terminal Phosphorylation by Insulin in Obesity and Type 2 Diabetes Mellitus
Journal of Clinical Endocrinology and Metabolism, 10/29/09 Relevance Score: 41%