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See Latest ArticlesPomegranate fruit extract impairs invasion and motility in human breast cancer
Integrative Cancer Therapies , 10/12/09
Khan GN et al. – Inhibition of motility and invasion by PFEs, coincident with suppressed RhoC and RhoA protein expression, suggests a role for these defined extracts in lowering the metastatic potential of aggressive breast cancer species.
Methods- Investigated effect of novel, defined PFE consisting of both fermented juice and seed oil on NF-kB pathway, which is constitutively active in aggressive breast cancer cell lines
- Effects of PFE on NF-kB—regulated cellular processes such as cell survival, proliferation, and invasion also examined
- Analytical characterization of bioactive components of PFE revealed active constituents, mainly ellagitannins and phenolic acids in aqueous PFE and conjugated octadecatrienoic acids in lipid PFE derived from seed
- Aqueous PFE dose-dependently inhibited NF-kB—dependent reporter gene expression associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression
Today in Alternative Therapies...keeping you current
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Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
Molecular Cancer, 11/20/09
Effectiveness of Traditional Chinese Medicine for Liver Protection and Chemotherapy Completion among Cancer Patients
Evidence-based Complementary and Alternative Medicine , 11/20/09
Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma
Cancer Treatment Reviews, 11/19/09
Today in Breast...keeping you current
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Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis
Cancer Letters, 11/20/09
Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors
Molecular Cancer, 11/20/09
Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration
World Journal of Surgical Oncology, 11/20/09
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