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Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways
Haematologica, 10/12/09
Segarra M et al. – Disruption of integrin–mediated signaling may be an important mechanism through which Thd and analogs impair tumor cell interactions with the microenvironment. The unexpected Thd effects on Akt activation indicate the need of further studies to elucidate whether interfering with Akt downstream effects would synergize with Thd anti–tumor activity.
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Today in Basic Science/Genetics...keeping you current
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Tumour markers predictive of successful treatment of breast cancer with primary endocrine therapy in patients over 70 years old: A prospective study
Critical Reviews in Oncology/Hematology, 12/10/09
A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy
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Expression of Hiwi in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis
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Today in Leukemia/Lymphoma...keeping you current
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Optimising the conditioning regimen for acute myeloid leukaemia
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