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van Beers EJ et al. – Sickle cell disease (SCD) is characterized by a hypercoagulable state involving multiple factors, including chronic hemolysis and circulating cell–derived microparticles (MPs). There is still no consensus on the cellular origin of such MPs and the exact mechanism by which they may support coagulation activation in SCD. The authors conclude that the procoagulant state in SCD is partially explained by the factor XI–dependent procoagulant properties of circulating erythrocyte–derived MPs.


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