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Association between plasma total cholesterol concentration and incident prostate cancer in the CLUE II cohort
Cancer Causes and Control, 10/13/09

Mondulet AM et al. –This study supports two prior ones suggesting that cholesterol influences risk of high-grade prostate cancer, and indirectly supports the hypothesis that cholesterol-lowering is a mechanism by which statins are protective.

• Prospective study
• 6,816 male county residents aged 35+ years old who did not have cancer diagnosis at baseline in 1989
• Plasma cholesterol, measured enzymatically at baseline categorized by clinical cutpoints
• Cox proportional hazards regression used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total (n = 438) and high-grade (Gleason sum ≥ 7, n = 137) prostate cancer

• Compared to men with high cholesterol (≥ 240 mg/dl), men with desirable (< 200 mg/dl) or borderline (200 to < 240 mg/dl) levels were less likely to develop high-grade prostate cancer, particularly when restricting to organ-confined cases and among men with higher BMI
• Results unchanged after excluding cholesterol-lowering drug users
• Cholesterol not associated with total prostate cancer

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