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Awad T et al. – Currently, no large well–planned clinical investigations have been conducted to establish the potential benefits and harms associated with treating liver cell cancer patients with cryotherapy. Nor have any such investigations been undertaken to establish the superiority or inferiority of cryotherapy compared with other treatments for liver cell cancer. At present, there is no evidence to support or refute the alleged and potential benefits of cryotherapy. Large well–designed randomised clinical trials are feasible and are necessary to define the role of cryotherapy in the treatment of hepatocellular carcinoma. At present, there is no evidence to recommend or refute cryotherapy for patients with hepatocellular carcinoma.



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