Oncology Medical News about Somatic Single Hits

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Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the Prostate
Cancer Cell, 10/12/09

Wang L et al. – In both normal and malignant prostate tissues, FOXP3 is both necessary and sufficient to transcriptionally repress cMYC, the most commonly overexpressed oncogene in prostate cancer as well as among the aggregates of other cancers. FOXP3 is an X–linked prostate tumor suppressor in the male. Because the male has only one X chromosome, our data represent a paradigm of “single genetic hit” inactivation–mediated carcinogenesis.

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Molecular diagosis of von Willebrand disease

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Spectrum of anemia associated with chronic liver disease

New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia
Journal of Clinical Oncology, 10/12/09 Relevance Score: 65%

Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism
Cancer Prevention Research, 10/08/09 Relevance Score: 64%

A Vascular Access Team Can Increase AV Fistula Creation in Pediatric ESRD Patients: A Single Center Experience
Seminars in Dialysis, 10/05/09 Relevance Score: 46%

The prevalence of human papillomavirus type 58 in Chinese patients with cervical carcinoma and its influence on survival
Clinical Oncology, 11/12/09 Relevance Score: 45%

A birth of twins-one boy and one girl-from a single embryo transfer and a possible natural pregnancy
Journal of Assisted Reproduction and Genetics, 10/20/09 Relevance Score: 44%