Oncology Medical News about Lymphotoxins

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Lymphotoxins: New Targets for Hepatocellular Carcinoma
Cancer Cell, 10/12/09

Villanueva A et al. – In this issue of Cancer Cell, Haybaeck et al. unravel the role of lymphotoxin pathway in the development of hepatocellular carcinoma (HCC). Aberrant activation of this cascade in mice livers recapitulates the stages of fibrosis and inflammation that precedes human liver cancer, providing a novel family of potential therapeutic targets.

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Soluble lymphotoxin is an important effector molecule in GVHD and GVL
Blood, 10/02/09 Relevance Score: 84%

Id2-, ROR{gamma}t-, and LT{beta}R-independent initiation of lymphoid organogenesis in ocular immunity
Journal of Experimental Medicine, 11/03/09 Relevance Score: 80%

LIGHT is associated with hypertriglyceridemia in obese subjects and increased cytokine secretion from cultured human adipocytes
International Journal of Obesity, 10/12/09 Relevance Score: 80%