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See Latest ArticlesYoung adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: a report from the childrens oncology group
Journal of Clinical Oncology, 10/12/09
Nachman JB et al. – Young adult patients with ALL showing a rapid response to induction chemotherapy benefit from early intensive postinduction therapy but do not benefit from a second interim maintenance and delayed intensification phase. Given the excellent outcome with this chemotherapy, there seems to be no role for the routine use of allogeneic stem-cell transplantation in first remission for young adults with ALL.
Methods- CCG 1961 entered patients with ALL 1 to 21 years of age with initial WBC count ≥ 50,000/?L and/or age ≥ 10 years.
- Randomly assigned therapies evaluated impact of postinduction treatment intensification on outcome
- 5-year event-free and overall survival rates for young adult patients are 71.5% and 77.5%
- Rapid responder patients randomly assigned to augmented therapy had 5-year event-free survival of 81.8% as compared with 66.8% for patients receiving standard therapy
- 1 versus 2 interim maintenance and delayed intensification courses had no significant impact on event-free survival
- WBC count more than 50,000/?L was adverse prognostic factor
Today in Leukemia/Lymphoma...keeping you current
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Peripheral T-cell lymphoma gene expression profiling and potential therapeutic exploitations
British Journal of Haematology, 11/20/09
Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression
Molecular Cancer, 11/20/09
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
Molecular Cancer, 11/20/09
Today in Pediatric Heme/Oncology...keeping you current
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Randomized Trial and Pharmacokinetic Study of Pegfilgrastim versus Filgrastim after Dose-Intensive Chemotherapy in Young Adults and Children with Sarcomas
Clinical Cancer Research, 11/20/09
Development and preliminary testing of a Paediatric Version of the Haemophilia Activities List (pedhal)
Haemophilia, 11/18/09
Iron deficiency anemia in infancy and reach and grasp development
Infant Behavior and Development, 11/18/09
Today in Pharmacology/Therapy...keeping you current
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Toxicity of Bisphosphonates
Journal of Palliative Medicine, 11/20/09
Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration
World Journal of Surgical Oncology, 11/20/09
Lenalidomide, Melphalan, and Prednisone Association Is an Effective Salvage Therapy in Relapsed Plasma Cell Leukaemia
Journal of Oncology, 11/20/09
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