Oncology Medical News about Bisphosphonate-Related Osteonecrosis

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Longitudinal Cohort Study of Risk Factors in Cancer Patients of Bisphosphonate-Related Osteonecrosis of the Jaw
Journal of Clinical Oncology, 10/12/09

Vahtsevanos K et al. – The conclusions of this study validated dental extractions and use of dentures as risk factors for ONJ development. Ibandronate and pamidronate at the dosages and frequency used in this study seem to exhibit a safer drug profile concerning ONJ complication; however, randomized controlled trials are needed to validate these results. Before initiation of a bisphosphonate, patients should have a comprehensive dental examination. Patients with a challenging dental situation should have dental care attended to before initiation of these drugs.

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Athanassios Kyrgidis, 10/13/09

Smoking, periodontitis, and root canal treatment did not increase risk for ONJ in patients receiving bisphosphonates. CPITN was not a predictor for ONJ development. Based on presented evidence, we concluded that it is the number of zoledronate doses that confers a higher risk for ONJ development and not the number of bisphosphonate doses in general. The data derived from the present study concern patients with multiple myeloma, breast cancer, and prostate cancer. However, they could also apply to patients with lung cancer who will survive beyond their life expectancy. ONJ does not seem to be less frequent among patients with breast cancer when controlled for possible confounders.

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