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See Latest ArticlesTherapy-induced PML/RARA Proteolysis and Acute Promyelocytic Leukemia Cure
Clinical Cancer Research, 10/12/09
Nasr R et al. – Cyclic AMP triggered PML/RARA phosphorylation also enhances RA–induced APL regression, PML/RARA degradation, and LIC clearance, raising new options for therapy–resistant patients. Although differentiation has a major role in debulking of the tumor, PML/RARA degradation seems to be the primary basis for APL eradication by the RA–As association. Oncoprotein degradation could be a general therapeutic strategy that may be extended beyond APL.
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Today in Basic Science/Genetics...keeping you current
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BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML)
Annals of Hematology, 12/01/09
In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer
Journal of Clinical Oncology, 12/01/09
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
BMC Cancer, 12/01/09
Today in Leukemia/Lymphoma...keeping you current
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BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML)
Annals of Hematology, 12/01/09
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non Hodgkin's lymphoma and chronic lymphocytic leukemia
Blood, 12/01/09
Cost and effectiveness of reduced-intensity and conventional allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndrome
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