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See Latest ArticlesAll-Trans Retinoic Acid-Induced Focal Myositis, Synovitis, and Mononeuritis
Journal of Clinical Rheumatology (JCR), 10/14/09
Yu W et al. – Here the authors report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all–trans retinoic acid therapy. The authors review the existing literature on this rare clinical entity, all–trans retinoic acid–induced myositis. This condition can manifest as fever, myalgia, arthralgia, and Sweet syndrome, accompanied by distinct magnetic resonance findings involving the lower extremity musculature. Treatment consists of discontinuation of the offending drug and often high dose corticosteroids.
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