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Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk
International Journal of Epidemiology, 10/08/09
Marron M et al. – These results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.
Methods- The authors pooled individual–level data from case–control studies in the International Head and Neck Cancer Epidemiology Consortium.
- Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls).
- The authors estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models.
- Quitting tobacco smoking for 1–4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61–0.81 compared with current smoking], with the risk reduction due to smoking cessation after >=20 years (OR 0.23, CI 0.18–0.31), reaching the level of never smokers.
- For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after >=20 years of quitting (OR 0.60, CI 0.40–0.89 compared with current drinking), reaching the level of never drinkers.
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