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Estimated dose to the rectum and colon in prostate cancer patients treated with exclusive radiation therapy presenting a secondary colorectal malignancy
Clinical Oncology, 10/07/09

Weber DC et al. – These data suggest that the administered dose after EBRT for prostate cancer to the colon, excluding the rectum, may be below the Gy unit in sCRC patients.

Methods

Data from population-based cancer registry of 1134 prostate cancer patients
11/264 (4.2%) patients treated with EBRT presented a sCRC
To evaluate dose delivered to colon and rectum, each individual index patient matched with study case and, using index case treatment characteristics, dose calculations were carried out on the latter

Results

Median maximum, mean and minimum doses delivered to colon or rectum affected by sCRC were 39.3 , 5.4 and 0.6 Gy, respectively
All but three sCRCs occurred outside treatment fields
Estimated rectal doses after prostate radiation therapy substantially higher than those delivered to non-rectal colic structures , but only one (9%) patient presented a rectal cancer
Differential mean doses given to rectosigmoid junction and sigmoid colon, with or without sCRC, not different

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