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Ruan C – The structure of recombinant vWF within transfected COS–7 cells and the secretion of highmolecular–weight (HMW) multimers were similar to wild–type vWF. HMW forms of vWF multimers were absent in plasma but present in platelets. The mutation corresponds to the group II type 2A vWD characterized by normal secretion of all vWF multimers.

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