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Challenges of defining reliable clinical surrogate end points in haemophilia trials: a critical review
Blood Coagulation & Fibrinolysis, 10/07/09

Amby LK et al. – The results of this review highlight that several efficacy end points are frequently combined in order to provide a more comprehensive assessment of efficacy. Key limitations of current methodology are the subjectivity of assessment by either the patient or clinician, and the incomparability of results between trials.

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