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See Latest ArticlesAn A13 Repeat within the 3'-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression
Cancer Research, 10/06/09
Yuan Z et al. – Cell lines with an EGFR 3'–UTR mutation and that were wild–type (WT) for downstream signaling mediators in the Ras/BRAF and PIK3CA/PTEN pathways were sensitive to EGFR inhibition, whereas those harboring mutations in these signaling mediators were not. Furthermore, in cell lines WT for downstream signaling mediators, those with EGFR 3'–UTR mutations were more sensitive to EGFR inhibition than EGFR 3'–UTR WT cells, suggesting that this mutation provides a growth advantage to this subset of MSI colon tumors.
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Today in Basic Science/Genetics...keeping you current
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Expression of p16 in benign and malignant cystic squamous lesions of the neck
Human Pathology, 12/19/09
Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas
Human Pathology, 12/19/09
Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions
Human Pathology, 12/19/09
Today in Colorectal Cancer/Polyps...keeping you current
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Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression
Genes, Chromosomes and Cancer, 12/19/09
TGFB1 509 C/T polymorphism and colorectal cancer risk: a meta-analysis
Medical Oncology, 12/17/09
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
Cancer Chemotherapy and Pharmacology, 12/17/09
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