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See Latest ArticlesClinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias
Cancer Chemotherapy and Pharmacology, 10/05/09
Norris R et al. – Aminopterin does not appear to offer any advantage over methotrexate for the treatment of childhood ALL.
Methods- Compared in vitro cytotoxicity of methotrexate, aminopterin, pemetrexed, and talotrexin
- Panel of 6 pediatric leukemia and lymphoma cell lines using sulforhodamine B assay
- Also contrasted activity of drugs in context of clinically achievable (tolerable) drug exposures using area under plasma concentration–time curve (AUC)
- Defined each agent’s clinical potency index (CPI) as AUC achieved with standard pediatric dosing regimens divided by in vitro IC50
- Across all cell lines, talotrexin (median IC50 7 nM) and aminopterin (median IC50 17 nM) had lower IC50’s than methotrexate (median IC50 78 nM) and pemetrexed (median IC50 155 nM)
- CPI for methotrexate (median 0.9) significantly greater than that for aminopterin (median 0.4)
- CPI for methotrexate (median 0.9)significantly greater than that for aminopterin (median 0.4)
- Pemetrexed had significantly better CPI (median 13) than traditional antifols
Today in Leukemia/Lymphoma...keeping you current
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microRNAs in acute myeloid leukemia: Expression patterns, correlations with genetic and clinical parameters, and prognostic significance
Genes, Chromosomes and Cancer, 12/19/09
Cytogenetics of long-term survivors of ETV6-RUNX1 fusion positive acute lymphoblastic leukemia
Genes, Chromosomes and Cancer, 12/19/09
The clinicopathological analysis of 303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan
Annals of Hematology, 12/18/09
Today in Pediatric Heme/Oncology...keeping you current
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Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population
Cancer Science, 12/18/09
Early elevation of C-reactive protein correlates with severe infection and non-relapse mortality in children undergoing allogeneic stem cell transplantation
Biology of Blood and Marrow Transplantation, 12/17/09
Unrelated cord blood transplantation in pediatric patients: a report from Saudi Arabia
Bone Marrow Transplantation, 12/17/09
Today in Pharmacology/Therapy...keeping you current
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A phase II trial of trastuzumab plus weekly ixabepilone and carboplatin in patients with HER2-positive metastatic breast cancer: An Eastern Cooperative Oncology Group Trial
Breast Cancer Research and Treatment, 12/18/09
Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: Results from a randomized phase II study
Palliative Medicine, 12/18/09
The effects of gefitinib in tamoxifen-resistant and hormone-insensitive breast cancer: A phase II study
International Journal of Cancer, 12/18/09
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