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Structure-activity relationships between the Aconitum C20-diterpenoid alkaloid derivatives and the growth suppressive activities of Non-Hodgkins lymphoma Raji cells and human hematopoietic stem/progenitor cells
Investigational New Drugs, 10/08/09

Hazawa M et al. – The atisine type structure characteristic of C20–diterpenoid alkaloids plays a very important role in the pharmacological properties. In particular, the C–11 residues are an important component for the anti–tumor properties and for the lower toxicity to hematopoiesis.

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