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Peroxisome proliferator-activated receptor gamma agonists potentiate the cytotoxic effect of valproic acid in multiple myeloma cells
British Journal of Haematology, 10/08/09
Aouali N et al. – The potentiation of the effect of VPA by pioglitazone was mediated by higher acetylation levels of histones H3 and H4 compared to levels induced by HDAC inhibitors alone. This association reveals a new promising chemotherapeutic combination to be tested in MM.
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Today in Basic Science/Genetics...keeping you current
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Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma
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Today in Myeloproliferative Dz...keeping you current
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The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan
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