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Local Biosynthesis of Estrogen in Human Endometrial Carcinoma through Tumor-Stromal Cell Interactions
Clinical Cancer Research, 10/06/09
Takahashi–Shiga N et al. – These results indicate the contribution of not only E2 but also E1 to cancer cell proliferation in endometrial carcinoma. The study may provide important information on metabolism and synthesis of intratumoral estrogens with regard to the etiology and progression of endometrial carcinoma, thus helping to achieve improved clinical responses in patients with endometrial carcinoma, who are treated with aromatase inhibitors.
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