Oncology Medical News about multiple myeloma

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Recommendations on the use of 18F-FDG PET in oncology

3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Correlation between losses of IGH or its segments and deletions of 13q14 in t(11;14) (q13;q32) multiple myeloma
Genes, Chromosomes and Cancer, 10/02/09

Trakhtenbrot L et al. – Multiple myeloma (MM) is a malignancy of the plasma cells (PCs) characterized by a wide variety of genetic and chromosomal abnormalities. In recent years, major attention was drawn to the significance of chromosomal aberrations involving chromosome arm 13q and the IGH region on chromosome band 14q32 as a prognostic indicator in MM. In contrast, the authors did not find any association between delta 13 and deletions of the IGH gene or its segments in the MM patients with t(4;14)(p16;q32).

Exclusive Author Commentary
Luba Trakhtenbrot, 10/08/09

In recent years, major attention was drawn to the significance of chromosomal aberrations involving chromosome arm 13q and the IGH region on chromosome band 14q32 as a prognostic indicator in MM. In this study we found 15 different variants of the translocation t(11;14) that are the consequence of different 11q13 breakpoints and various deletions of IGH segments and duplications and losses of the IGH gene. A strong association between deletions of chromosome 13 (?13) and specific variants of this translocation was found: the common translocation t(11;14) was found only in the MM cases with normal chromosome arm 13q, while variants with deletion of the IGH gene or its segments were found only in MM cases with ?13. In contrast, we did not find any association between ?13 and deletions of the IGH gene or its segments in the MM patients with t(4;14)(p16;q32).

<< Previous
Immunohistochemical expression of E-cadherin in sclerosing...

Next >>
Soluble lymphotoxin is an important effector molecule in GVHD and...