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Narayanan V et al. – This review article examines the etiopathogenesis and management strategies of fatigue in cancer. The complexity of fatigue warrants a transdisciplinary approach for an effective management. It includes pharmacological interventions, psycho education, individual exercises, couns eling, and information. Treatment interventions have to be individualized and each patient should have his or her own plans to combat fatigue. This needs sustained effort. Prompt symptom assessment and early intervention is the key to a successful management plan. Fatigue experienced by a patient at the close of life is a normal phenomenon, and a vigorous attempt for reversal in the final hours may not be appropriate as it may cause a re–entry into the world of suffering. Hence, a judicious approach is most necessary in dealing with cancer–related fatigue.

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