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Iron Sequestration and Anemia of Inflammation
Seminars in Hematology, 10/06/09
Ganz T et al. – Hepcidin excess causes the endocytosis and proteolysis of the sole known cellular iron exporter, ferroportin, trapping iron in macrophages and iron–absorbing enterocytes. The supply of iron to hemoglobin synthesis becomes limiting, eventually resulting in anemia. Depending on the details of the underlying disease, other inflammation–related mechanisms may also contribute to anemia.
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