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See Latest ArticlesCo-expression of Hif1alpha and CAIX is associated with poor prognosis in oral squamous cell carcinoma patients
Journal of Oral Pathology and Medicine, 10/01/09
Eckert AW et al. – A co-detection of low Hif1?/CAIX expression is significantly correlated with a better prognosis for OSCC patients, which may have implications for therapy options for these patients.
Methods- Statistical analysis of immunohistochemical results
- Clinical parameters including survival outcomes
- 80 OSCC patients
- Patients with low expression of both proteins survived average 54.8 months
- Increased expression of Hif1? in tumors combined with low expression of CAIX survived on average only 37.6 months
- In multivariate Cox's regression hazard analysis, patients with low expression of Hif1?/CAIX had best prognosis
- Patients with increased Hif1? and low CAIX expression carried 4.97-fold increased risk of tumor-related death
Today in Basic Science/Genetics...keeping you current
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Serum calcium levels are elevated among women with untreated postmenopausal breast cancer
Cancer Causes and Control, 11/03/09
Prognostic and predictive value of HER2 extracellular domain in metastatic breast cancer treated with lapatinib and paclitaxel in a randomized phase III study
Journal of Clinical Oncology, 10/29/09
Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers
Journal of Clinical Oncology, 10/29/09
Today in GI Oncology...keeping you current
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Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer
Journal of Clinical Oncology, 11/02/09
Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
Journal of Clinical Oncology, 10/29/09
Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer
Journal of Clinical Oncology, 11/03/09
Today in Head and Neck...keeping you current
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Primary extranodal marginal zone lymphoma of the uvea associated with massive diffuse epibulbar extension and focal infiltration of the optic nerve and meninges, clinically presented as uveitis masquerade syndrome: a case report
Medical Oncology, 10/16/09
Thyroid lymphoma and airway obstruction – is there a rationale for surgical management?
International Journal of Clinical Practice, 10/19/09
Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: Results from a phase II prospective trial
Journal of Clinical Oncology, 11/25/09
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