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See Latest ArticlesA Pharmacokinetic Study of Plerixafor in Subjects with Varying Degrees of Renal Impairment
Biology of Blood and Marrow Transplantation, 09/30/09
MacFarland R et al. – The safety profile was very similar in the subjects with renal impairment and controls. No renal impairment–related trends in the incidence of adverse events were apparent. A plerixaflor dose reduction to 160microg/kg in patients with a creatinine clearance value <=50mL/min is expected to result in exposure similar to that in patients with normal to mildly impaired renal function.
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Today in BMT/SCT...keeping you current
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Unpredictability of iv Busulfan pharmacokinetics in children undergoing hematopoietic stem cell transplant for advanced beta thalassemia: Limited toxicity with a dose adjustment policy
Biology of Blood and Marrow Transplantation, 12/09/09
High levels of B-cell activating factor during the peri-transplant period are associated with the reduced incidence of acute graft-versus-host disease following the myeloablative allogeneic stem cell transplantation
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Improved survival with inhibitory Killer Immunoglobulin Receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation
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Today in Pharmacology/Therapy...keeping you current
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A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy
Breast Cancer Research and Treatment, 12/09/09
A randomized, placebo-controlled trial (NCIC CTG MAP1) examining the effects of letrozole on mammographic breast density and other end organs in postmenopausal women
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Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: Results of a pharmacokinetic/pharmacodynamic meta-analysis
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