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Thrombin-inducible platelet adhesion and regulation of the platelet seven-transmembrane thrombin receptor-1 (PAR-1): Effects of unfractionated heparin and lepirudin
Platelets, 09/28/09
Reiter N et al. – Heparin may induce platelet activation and even heparin–induced thrombocytopenia. Lepirudin has been approved for HIT treatment. Heparin and lepirudin inhibit thrombin–inducible platelet activation in vitro to a similar extent.
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